Difficulties and prospects in the treatment of Graves′ disease
10.3760/cma.j.cn311282-20210720-00470
- VernacularTitle:Graves病治疗的困惑与希望
- Author:
Wenjin CUI
1
;
Pingping XIANG
;
Guofang CHEN
;
Chao LIU
Author Information
1. 南京中医药大学附属中西医结合医院，江苏省中医药研究院，内分泌科
- Keywords:
Graves′ disease;
B lymphocytes;
Thyroid stimulating hormone receptor;
Immunotherapy;
Thermotherapy;
Traditional Chinese medicine
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(4):353-358
- CountryChina
- Language:Chinese
-
Abstract:
Although traditional treatment for Graves′ disease(GD) displays some effects, it is imperative to explore new treatment methods. Based on the pathogenesis of GD, biologic agents developed by consumption of B lymphocytes and acting on thyroid stimulating hormone receptor(TSHR), such as monoclonal antibodies, TSHR antagonists and epitopes, can provide more options for patients with GD, and some new drugs are expected to be put into clinical practice. By restoring the damaged immune system and maintaining normal thyroid function continuously, it can avoid the disadvantages of conventional therapies such as long-term treatment, induction or aggravation of Graves ophthalmopathy, permanent hypothyroidism, and other complications. Preliminary experience suggests that thermotherapy is effective and safe for patients with refractory GD. In addition, the traditional Chinese medicine improves the symptoms and thyroid function of GD patients.The emergence of new therapeutic modalities and techniques will provide new approaches for the future treatment of GD and help clinicians to make the best decision.
