Approach to the patient with pituitary metastases initially manifested as central diabetes insipidus
10.3760/cma.j.cn311282-20210822-00536
- VernacularTitle:以中枢性尿崩症为首发症状的垂体转移癌的临诊应对
- Author:
Feng GUO
1
;
Shasha WANG
;
Guijun QIN
;
Zhizhen LI
;
Yanyan ZHAO
;
Xialian LI
;
Lina WU
;
Jiao WANG
;
Ying ZHANG
;
Gaofei REN
Author Information
1. 郑州大学第一附属医院内分泌科 450052
- Keywords:
Pituitary metastases;
Central diabetes insipidus;
Hypopituitarism;
Imaging changes;
Targeted therapy
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(4):330-334
- CountryChina
- Language:Chinese
-
Abstract:
The data of 10 patients with pituitary metastases were retrospectively analyzed, including tumor origin, clinical features, imaging characteristics, diagnosis and differential diagnosis, treatment and prognosis. The results showed that the average age of 10 patients at the time of consultation was 62.0 years. Nine metastases were originated from lung cancer and one from breast cancer. All patients started with central diabetes insipidus, and some of them accompanied with hypopituitarism, as well as occupancy manifestations such as headache, blurred vision, etc. MRI showed abnormalities in the pituitary stalk and posterior pituitary, four of which showed characteristic " dumbbell-shaped" changes. Three patients with epidermal growth factor receptor(EGFR)-mutated lung adenocarcinoma revealed improvement in both primary lesion and pituitary metastases after targeted therapy.
