New insights on aldosterone-producing cell clusters in the pathogenesis of primary aldosteronism
10.3760/cma.j.cn311282-20210512-00293
- VernacularTitle:醛固酮合成细胞簇(APCC)在原发性醛固酮增多症发病中的研究进展
- Author:
Juan FEI
1
;
Yi YANG
;
Jinbo HU
;
Linqiang MA
;
Junlong LI
;
Ying SONG
;
Qifu LI
;
Xiaoyu LI
;
Shumin YANG
Author Information
1. 重庆医科大学附属第一医院内分泌科 400016
- Keywords:
Aldosterone-producing cell clusters;
Primary aldosteronism;
CYP11B2
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Primary aldosteronism(PA) is one of the most common secondary hypertension, the pathogenesis is still not fully understood. Aldosterone synthase(CYP11B2) was thought to be continuously expressed in the zona glomerulosa of the adrenal cortex. In recent years, it is found that there were discontinuous CYP11B2 positive cell clusters in adrenal cortex via immunohistochemical staining, and proposed the concept of aldosterone-producing cell clusters(APCC). Thenceforwarding a growing body of studies suggest that there may be a potential causal link between APCC and PA. This article summarizes the latest studies on APCC and provide an update on the potential role of APCC in the pathogenesis of PA.
