Effects of subclinical hypothyroidism during pregnancy treated with LT 4 on the growth and neuropsychology of offspring aged 0-36 months: A cohort study
10.3760/cma.j.cn311282-20210520-00316
- VernacularTitle:经LT 4治疗的妊娠期亚临床甲状腺功能减退症对子代0~36月龄生长发育及神经心理影响的队列研究
- Author:
Shuang ZHANG
1
;
Nan LI
;
Wei DONG
;
Wei LI
;
Weiqin LI
;
Leishen WANG
;
Huikun LIU
;
Jing WEN
;
Junhong LENG
Author Information
1. 天津市妇女儿童保健中心项目办公室 300070
- Keywords:
Subclinical hypothyroidism;
Pregnancy;
Offspring;
Growth development;
Neuropsychology
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(2):112-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of subclinical hypothyroidism during pregnancy treated with LT 4 on the growth and neuropsychology of offspring aged 0-36 months. Methods:A maternal-infant cohort was established in healthy singleton pregnant women aged 20-45 years without history of thyroid disease. Women developing subclinical hypothyroidism during pregnancy were treated with LT4. The weight, length, and head circumference of the offspring were recorded between 0 to 36 months after birth. Meanwhile, infant nutrition and family support were investigated. The Neuropsychological Development Questionnaire of 0-6 year old children was used to evaluate the neurodevelopment of offspring.Results:A total of 186 mother-infant pairs were included. All subjects were divided into the euthyroidism(ETH) group( n=136) and subclinical hypothyroidism(SHT) group( n=50) according to maternal thyroid function during pregnancy. The Z-scores(adjusted by months of age and gender) of weight, length, weight/length at birth, weight/length at 1 month, head circumference at 6 months, length at 8 months, weight/length at 24 months of SHT group were lower than those of the ETH group( P<0.05). Furthermore, the language competence of the SHT offspring at 12 months of age was also lower than that of the ETH group( P<0.05). Maternal subclinical hypothyroidism treated with LT 4 did not significantly affect preterm delivery, low birth weight, and developmental quotient <85, but reduced the risk of macrosomia(AOR 0.206, 95% CI 0.046-0.929, P=0.040). Conclusion:Although women with subclinical hypothyroidism received LT 4 treatment during pregnancy, the offspring still may suffer adverse effects on their growth and neural development.
