Relation of weight change after twenty on subsequent diabetes risk
10.3760/cma.j.cn311282-20210607-00354
- VernacularTitle:成人20岁后体重变化与糖尿病患病风险的关联研究
- Author:
Hong LIAN
1
;
Feng LI
;
Yiqin QI
;
Li YAN
;
Diaozhu LIN
;
Lili YOU
Author Information
1. 中山大学孙逸仙纪念医院内分泌科，广州 510120
- Keywords:
Diabetes mellitus;
Weight change;
Correlation research
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(2):105-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between weight change from age 20 to middle age and diabetes risk.Methods:A total of 10 104 residents over 40 years old were recruited in Guangzhou. The final analysis data set is a cohort of 6 272 patients from the REACTION study. Quartile of weight changes from age 20 to middle-age was used as an independent variable to explore its association with newly diagnosed diabetes. Simple and multivariable logistic regression analysis were used to calculate OR and 95% CI. Results:The prevalence of newly diagnosed diabetes in study cohort was 15.7%. Weight changes from age 20 to middle-age was significantly higher in diabetes group( P<0.001). Logistic regression analysis found in general population and overweight people [24.0≤body mass index(BMI)<28.0 kg/m 2], after adjusting for gender, age, educational level, family history of diabetes, drinking, SBP, waist circumference, cholesterol, high-density lipoprotein-cholesterol(HDL-C), TG, ALT, AST, the risk of diabetes increased in line with the magnitude of weight change( P=0.081). While in group of lean, normal and obese adult, no significant association has been found. Conclusion:The risk of diabetes increased with weight change in general population and overweight people, indicating that weight change in adults after age of 20 was positively associated with diabetes. It is suggested the importance of weight management in the prevention of dialetes.
