Pregnancy and lymphocytic hypophysitis
10.3760/cma.j.cn311282-20210405-00217
- VernacularTitle:妊娠与淋巴细胞性垂体炎
- Author:
Yajing WANG
1
;
Li ZANG
;
Qian WEI
;
Guoqing YANG
;
Zhaohui LYU
Author Information
1. 中国人民解放军总医院第一医学中心内分泌科，北京 100853
- Keywords:
Lymphocytic hypophysitis;
Pregnancy;
Treatment;
Prognosis
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(1):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Lymphocytic hypophysitis(LYH) is a rare autoimmune disease, which is more common in women and is closely associated with pregnancy. For patients with lymphocytic hypophysitis, the clinical manifestations mainly depend on the speed of disease progression, the extent of lesions, the severity and stage of disease, which can present as mass effect, decreased anterior pituitary hormone function, and central diabetes insipidus, etc. Due to physical changes in pituitary anatomy and hormone levels, as well as restriction of imaging examinations during pregnancy, it poses greater challenge to establish diagnosis in perinatal patients, which demands a comprehensive assessment of the patient′s clinical symptoms and biochemical tests. For treatment, patients with hypopituitarism during pregnancy should be given hormone replacement therapy. Moreover, patients need to adopt optimized tailored therapy according to gestational age and various clinical manifestations. At present, there is no report on the adverse effects of LYH on pregnancy outcome and re-pregnancy. This review discusses the diagnosis, treatment and prognosis of patients with LYH during pregnancy, and provides reference for the clinical management of this condition.
