Approach to the patient with Cushing′s disease with a false negative result in inferior petrosal sinus sampling

VernacularTitle:双侧岩下窦静脉取血假阴性库欣病的临诊应对
Author: Xiangning LIU ¹ ; Lijia CUI ; Shi CHEN ; Lin LU ; Yong YAO
Author Information

1. 中国医学科学院，北京协和医学院，北京协和医院内科　100730
Keywords: Cushing′s disease; Bilateral inferior petrosal sinus sampling; Desmopressin
From: Chinese Journal of Endocrinology and Metabolism 2022;38(1):50-53
CountryChina
Language:Chinese
Abstract: Bilateral inferior petrosal sinus sampling(BIPSS), with or without desmopressin stimulation, is the gold standard in the diagnosis of Cushing′s disease. A few of patients with Cushing′s disease present a false negative result in BIPSS. These patients are often misdiagnosed as ectopic adrenocorticotropin(ACTH) syndrome(EAS). Here we report a case of Cushing′s disease with a false negative BIPSS, in the hope to aid clinical physicians in the differential diagnosis and treatment of ACTH-dependent Cushing′s syndrome.