Plasma microfibrillar associated protein 5 level in patients with polycystic ovary syndrome
10.3760/cma.j.cn311282-20210719-00467
- VernacularTitle:血浆微纤丝关联蛋白5水平在多囊卵巢综合征患者中的意义
- Author:
Mingyu LIAO
1
;
Xing LI
;
Huan ZHAO
;
Weixin LI
;
Liu SHI
;
Xiuli WANG
;
Hongting ZHENG
;
Min LONG
Author Information
1. 陆军军医大学第二附属医院内分泌科，重庆 400037
- Keywords:
Polycystic ovary syndrome;
Microfibrillar associated protein 5;
Glycolipid metabolism;
Insulin resistance
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(1):30-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess plasma microfibrillar associated protein 5(MFAP5) level in patients with polycystic ovary syndrome(PCOS), and to explore its relationship with glucose and lipid metabolism as well as sex hormones.Methods:Fifty PCOS patients and 65 healthy female subjects were selected as PCOS group and control group, respectively. Clinical data and plasma MFAP5 levels between the two groups were compared.Results:The plasma MFAP5 level in PCOS group was significantly higher than that in control group( P<0.01), and the plasma MFAP5 level in PCOS overweight subgroup was higher than that in control subgroup( P<0.01). No difference was observed in plasma MFAP5 level between the two non-overweight subgroups( P>0.05). Correlation analysis showed that plasma MFAP5 level was positively correlated with waist circumference, low density lipoprotein-cholesterol, fasting insulin, homoeostasis model assessment of insulin resistance index(HOMA-IR), HbA 1C, testosterone, LH/FSH ratio, and leukocyte( P<0.05 or P<0.01). There was no significant correlation of MFAP5 with body weight, body mass index(BMI), hip circumference, waist hip ratio, high density lipoprotein-cholesterol(HDL-C), triglyceride, total cholesterol, and blood glucose( P>0.05). In PCOS group, plasma MFAP5 level was positively correlated with body weight, BMI, waist circumference, hip circumference, total cholesterol, and leukocyte( P<0.05 or P<0.01). There was no significant correlation of MFAP5 with waist hip ratio, HDL-C, triglyceride, blood glucose, fasting insulin, HOMA-IR, leukocyte, and sex hormones( P>0.05). Multivariate logistic regression analysis showed that MFAP5 was an independent risk factor for PCOS( P<0.05). Conclusion:Plasma MFAP5 level is increased in PCOS patients and is closely related to BMI, waist circumference, hip circumference, and total cholesterol. Plasma MFAP5 is an independent risk factor for PCOS, which may be involved in the pathogenesis of PCOS.
