Effects of persistent isolated hypothyroxinemia in the first and second trimester of pregnancy on complications and adverse outcomes of pregnancy
10.3760/cma.j.cn311282-20210710-00445
- VernacularTitle:妊娠早中期持续孤立性低甲状腺素血症对妊娠期并发症及不良结局的影响
- Author:
Hui JIN
1
;
Fangyuan CHEN
;
Yueyue WU
;
Jun LIU
;
Xinmei HUANG
;
Zaoping CHEN
;
Li SHENG
;
Jiong XU
;
Bingbing ZHA
;
Mengxue YANG
;
Zhiyan YU
;
Rui ZHANG
;
Yue LI
Author Information
1. 复旦大学附属上海市第五人民医院药剂科 200240
- Keywords:
Pregnancy;
Isolated hypothyroxinemia;
Complications;
Adverse outcomes
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of persistent isolated hypothyroxinemia in the first and second trimester of pregnancy on complications and adverse outcomes of pregnancy.Methods:A retrospective analysis was conducted in 784 pregnant women including 111 cases of persistent isolated hypothyroxinemia in the first and second trimester of pregnancy and 673 pregnant women with normal thyroid function as control group. All women were registered and delivered in the Department of Obstetrics of our hospital from April 2016 to April 2017. The complications and adverse outcomes of pregnancy in the two groups were analyzed.Results:Age, body weight before pregnancy, body mass index(BMI), 1 h plasma glucose and 2 h plasma glucose during oral glucose tolerance test in persistent isolated hypothyroxinemia group were higher than those in control group( P<0.05), with increased incidence of anemia during pregnancy( P<0.05). However, there were no significant differences in the incidences of gestational diabetes mellitus and gestational hypertension between the two groups( P>0.05). No significant statistical differences were found in macrosomia, stillbirth, neonatal malformation, postpartum hemorrhage, acute delivery, premature delivery, fetal intrauterine development delay, and small full-term infants between the two groups( P>0.05). Logistic regression analysis showed that age( OR=1.1, 95% CI 1.0-1.1, P=0.002) and pre-pregnancy body weight( OR=1.0, 95% CI 1.0-1.1, P=0.046) were risk factors for the occurrence of persistent isolated hypothyroxinemia in the first and second trimesters of pregnancy. Persistent isolated hypothyroxinemia in the first and second trimesters was associated with anemia during pregnancy( OR=1.9, 95% CI 1.1-3.2, P=0.024). Conclusions:Pregnant women who are older and heavier before pregnancy should pay more attention to their thyroid function. Pregnant women with persistent isolated hypothyroxinemia in the first and second trimesters should be concerned for anemia.
