A study on the composite indices of femoral neck strength in non-low-weight postmenopausal women with type 2 diabetes mellitus in community
10.3760/cma.j.cn311282-20210627-00413
- VernacularTitle:社区非低体重绝经后2型糖尿病女性股骨颈强度综合指数的相关研究
- Author:
Didi LU
1
;
Yufan ZHANG
;
Ping ZHANG
;
Jindi WANG
;
Wenbin ZHOU
;
Tao YANG
;
Jingjing XU
;
Wei HE
Author Information
1. 南京医科大学第一附属医院内分泌科 210029
- Keywords:
Diabetes mellitus, type 2;
Postmenopausal women;
Bone mineral density;
Hip fracture;
Composite indices of femoral neck strength
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(1):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk of hip fracture, changes of composite indices of femoral neck strength and its influential factors in non-low-weight postmenopausal women with type 2 diabetes mellitus(T2DM).Methods:A total of 626 non-low-weight postmenopausal women were selected and divided into type 2 diabetes group, pre-diabetic group, and non-diabetic group according to the diagnostic criteria of the American Diabetes Association in 2010. Each participant completed the questionnaire, physical examination, laboratory examination, and Dual-energy X-ray absorptiometry(DXA) examination.Results:Hip fracture rate in T2DM group was significantly higher than that in non-diabetic group(3.4% vs 0.7%, P<0.05), while no significant difference was observed between pre-diabetic group and non-diabetic group(1.1% vs 0.7%, P>0.05). Bone mineral density(BMD) of lumbar spine 1-4, femoral neck, and total hip was comparable between T2DM group and non-diabetic group or pre-diabetic group and non-diabetic group, respectively( P>0.05). The composite indices of femoral neck strength in T2DM group was significantly lower than that in non-diabetic group( P<0.05), but there was no significant difference between pre-diabetic group and non-diabetic group( P>0.05). Regression analysis showed that age and body mass index were the main influential factors of the femoral neck bone mineral density and the composite indices of femoral neck strength( P<0.05). Conclusion:The composite indices of femoral neck strength could be used as one of the markers to evaluate the risk of hip fracture in type 2 diabetic patients.
