Correlation of smoking with tophi under ultrasound
10.3760/cma.j.cn311282-20210108-00014
- VernacularTitle:超声下痛风石与吸烟的相关性研究
- Author:
Shuguang HAN
1
;
Xiaoting CHEN
;
Nan LIANG
;
Haibing CHEN
Author Information
1. 上海交通大学附属第六人民医院内分泌与代谢科 200233
- Keywords:
Smoking;
Tophi;
Uric acid;
Risk factor
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(12):1091-1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between tophi detected by ultrasound and smoking.Methods:A total of 863 male gout patients over 18 years old in Shanghai Jiaotong University Affiliated Sixth People′s Hospital were selected. According to the results of ultrasound, patients were divided into two groups: non-tophi group ( n=527) and tophi group ( n=336). Independent sample t-test, Mann-Whitney U test or chi-square test were used for between-group comparison. Binary logistic regression was used to analyze independent influencing factors. Results:The proportion of smokers in non-tophi group and tophi group was 43.3% vs 65.5% respectively. There was significant difference between two groups ( P<0.01). With the increase of smoking index, the prevalence of tophi increases gradually ( P<0.05), so did the prevalence of multiple tophi as well as the number and size of gouty stone ( P<0.05). The proportion of tophi in other joints of foot in smokers was significantly higher than that in non-smokers ( P<0.05). The stratified analysis of smoking index showed that when 0400, the risk of developing gout was increased by 1.195 and 1.779 times, respectively ( OR=2.195, 95% CI 1.507-3.197, P<0.01; OR=2.779, 95% CI 1.761-4.385, P<0.01). Conclusion:Smoking is a risk factor for the occurrence of gouty stone. Patients with gout who smoke should quit smoking as soon as possible to reduce the risk of tophi.
