The association of abnormal thyroid stimulating hormone levels with elevated blood pressure among females of child-bearing potential
10.3760/cma.j.cn311282-20210420-00244
- VernacularTitle:育龄女性促甲状腺激素水平异常与血压升高的关联研究
- Author:
Qiaoyun DAI
1
;
Ting GUAN
;
Hongguang ZHANG
;
Xueying YANG
;
Juan YANG
;
Yue ZHANG
;
Dongmei ZHANG
;
Xu MA
;
Jun ZHAO
Author Information
1. 国家卫生健康委科学技术研究所人类遗传资源中心，北京 100081
- Keywords:
Females of child-bearing potential;
Thyroid stimulating hormone;
Prehypertension;
Hypertension
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(12):1075-1081
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between abnormal thyroid stimulating hormone (TSH) and elevated blood pressure among females of child-bearing potential.Methods:A total of 294 674 females of child-bearing age who participated in pre-pregnancy health examination in Shenzhen from 2013 to 2019 were selected. Demographic characteristics, blood pressure, TSH, fasting blood glucose and other indexes were collected. Multivariate logistic regression model was used to analyze the association between abnormal TSH levels and elevated blood pressure (including prehypertension and hypertension).Results:This study showed that females of child-bearing potential with prehypertension and hypertension accounted for 21.77% and 2.41%, respectively. Compared with females of child-bearing potential with normal TSH, the risk of prehypertension and hypertension increased by 34.0% ( OR=1.340, 95% CI 1.248-1.438) and 59.6% ( OR=1.596, 95% CI 1.301-1.938) among those with decreased TSH, respectively, whereas the risk of prehypertension and hypertension increased by 13.6% ( OR=1.136, 95% CI 1.076-1.198) and 38.0% ( OR=1.380, 95% CI 1.198-1.581) among those with elevated TSH, respectively. Subgroup analysis showed that abnormal TSH levels in most subgroups, such as age, ethnicity, educational level, occupation, spouse smoking, alcohol drinking, body mass index, and fasting blood glucose, were associated with the risk of elevated blood pressure. Heterogeneity test showed that the association between decreased TSH and elevated blood pressure was higher in females with high school and below or alcohol drinking, and the association between elevated TSH and elevated blood pressure was higher in females with college/bachelor′s degree and above or non-smoking spouse. Conclusion:There is a significant association between abnormal TSH levels and the risk of prehypertension and hypertension in females of child-bearing potential, and the association should be explored with stratified educational level, alcohol drinking, and spouse smoking status.
