Sugammadex versus neostigmine for reversal of rocuronium-induced residual neuromuscular blockade in patients undergoing renal transplantation: a large-scale, retrospective study
10.3760/cma.j.cn131073.20210728.01109
- VernacularTitle:舒更葡糖钠与新斯的明拮抗肾移植术患者罗库溴铵残余肌松效果的比较：大样本、回顾性研究
- Author:
Diansheng WU
1
;
Hongbin ZHOU
;
Zhuodan WANG
;
Huansen HUANG
Author Information
1. 广州医科大学附属第二医院麻醉科 510260
- Keywords:
Neostigmine;
Androstanols;
Renal transplantation;
Delayed emergence from anesthesia;
Neuromuscular blockade;
Sugammadex
- From:
Chinese Journal of Anesthesiology
2021;41(11):1316-1320
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy of sugammadex versus neostigmine on reversal of rocuronium-induced residual neuromuscular blockade in patients undergoing renal transplantation. Methods:The clinical data of patients undergoing kidney transplantation from donation after cardiac death in our hospital from January 2018 to December 2020 were retrospectively analyzed.Patients were divided into sugammadex group (group S) and neostigmine group (group N) according to the use of muscle relaxant antagonists.The onset time of antagonism, time of tracheal extubation, and time of postanesthesia care unit stay were recorded.The creatinine clearance rate was recorded before operation and at 1, 3, 5 and 7 days after operation.The occurrence of postoperative complications was recorded.Results:A total of 603 patients were enrolled in this study, with 278 patients in group S and 325 patients in group N. Compared with group N, the onset time of antagonism, time of extubation , and time of postanesthesia care unit stay were significantly shortened, the incidence of hypoxemia within 24 h after surgery and pulmonary infection occurred within 7 days after surgery was decreased ( P<0.05), and no significant change was found in the creatinine clearance rate at each time point and incidence of postoperative cardiovascular complications and graft complications in group S ( P>0.05). Conclusion:Compared with neostigmine, sugammadex can reverse rocuronium-induced residual neuromuscular blockade more quickly, which is helpful for early recovery with a higher safety when applied in the patients undergoing renal transplantation.
