The research progress in the treatment of advanced sarcomatoid renal cell carcinoma
10.3760/cma.j.cn112330-20210301-00106
- VernacularTitle:晚期肉瘤样肾细胞癌治疗进展
- Author:
Keruo WANG
1
;
Yuqi WU
;
Gang LI
Author Information
1. 天津医科大学第二医院泌尿外科，天津 300211
- Keywords:
Carcinoma, renal cell;
Sarcomatoid;
Therapeutics;
Research development;
Metastasis;
Immunotherapy
- From:
Chinese Journal of Urology
2022;43(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Sarcomatoid renal cell carcinoma is a highly malignant tumor with sarcomatoid dedifferentiation, which has rapid progression, high mortality rate and poor prognosis. Studies have shown that cytoreductive surgery, chemotherapy or targeted therapy are not effective to patients with advanced sarcomatoid renal cell carcinoma. With the further study of pathogenesis and molecular biological characteristics of sarcomatoid renal cell carcinoma, it is found that the expression levels of PD-1 and PD-L1 in it are higher than those of other subtypes, so the combination of immune checkpoint inhibitors and immunotherapy combined with targeted therapy have become the first-line therapy. This article mainly reviews the latest treatments for advanced sarcomatoid renal cell carcinoma, including surgery, chemotherapy, targeted drugs, immunotherapy and so on.
