A case report of novel endocrine therapy in a patient with metastatic hormone sensitive prostate cancer
10.3760/cma.j.cn112330-20210908-00007
- VernacularTitle:恩扎卢胺联合多西他赛治疗高危转移性激素敏感性前列腺癌一例报告
- Author:
Chaoqian CHEN
1
;
Songzhe PIAO
;
Tao HONG
;
Mang KE
Author Information
1. 温州医科大学附属台州医院泌尿外科，临海 317000
- Keywords:
Prostatic neoplasms;
Metastatic;
Hormone sensitive;
Novel endocrine therapy;
Chemotherapy
- From:
Chinese Journal of Urology
2021;42(Z2):21-25
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the comprehensive clinical effect of early application of novel endocrine therapy combined with docetaxel for high-risk hormone-sensitive prostate cancer. A 62 year old patient was admitted due in April 2020, presented with numbness and weakness in both lower limbs for 10 days. Multiple bone metastases including thoracic vertebra and sternum was found by thoracic magnetic resonance imaging. Total resection of T5 vertebral tumor, spinal canal decompression were performed. Bone metastases was confirmed by postoperative pathological examination, and the tumor that meets clinical diagnostic criteria for prostate acinar adenocarcinoma. The post-operative PSA was 960.602 ng/ml. Based on history, imaging, pathological and serological findings, the diagnosis of high-risk metastatic hormone-sensitive prostate cancer (mHSPC), with high tumor burden was considered. The clinical stage was T 4N 1M 1. After treatment with novel endocrine therapy (enzalutamide+ androgen deprivation therapy, 3 months) combined with docetaxel(75mg/m 2, once every 3 weeks, plus prednisone 5mg, twice daily, for 4 circles), the patient’s symptoms had improved and the lesion was found to be smaller. Novel endocrine therapy combined with docetaxel can effectively suppress disease progression. The most common adverse effects include hot flushes, fatigue, headache, and hematologic toxicity (anemia, thrombocytopenia, and neutropenia) were not observed in this case. This case exemplifies novel endocrine therapy combined with DTX therapy may be one of the effective treatment options for high-risk metastatic hormone sensitive prostate cancer.
