The role of the gut microbiota in the pathogenesis of sarcopenia
10.3760/cma.j.issn.0254-9026.2022.05.020
- VernacularTitle:肠道微生态在肌少症发病机制中的作用
- Author:
Zuojun SUN
1
;
Li'an ZHU
;
Ningyuan FANG
;
Yaomin HU
Author Information
1. 上海交通大学医学院附属仁济医院老年病科，上海 200127
- Keywords:
Gut microbiota;
Sarcopenia;
Muscle mass;
Muscle function
- From:
Chinese Journal of Geriatrics
2022;41(5):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Sarcopenia is a progressive syndrome associated with aging, generalized loss of skeletal muscle mass, muscle strength and function.It is closely related to the occurrence of adverse events such as ambulatorydysfunction, falls and fractures in the elderly, and seriously affects the quality of life of the elderly.The etiology of sarcopenia has not been fully elucidated.Various pathophysiological mechanisms such as reduced exercise, genetic factors, age-related hormone changes, malnutrition and insufficient protein intake, decreased neuromuscular function, pro-inflammatory cytokines, and myocyte apoptosis are possible factors.Recent studies have found that intestinal microecological changes may be implicated in the occurrence and development of sarcopenia.In this article, we reviewed intestinal microecological changes and their possible role in the mechanisms underlying sarcopenia.
