The Prognostic Significance of Blood and Lymphatic Vessels Invasion of Upper Urinary Tract Transitional Cell Carcinoma.
- Author:
Tong Keun SHIN
1
;
Hae Young PARK
;
Young Nam WOO
Author Information
1. Hanyang University Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
transitional cell carcinoma;
upper urinary tract;
vascular invasion;
prognosis
- MeSH:
Carcinoma, Transitional Cell*;
Humans;
Incidence;
Lymphatic Vessels*;
Neoplasm Metastasis;
Prognosis;
Retrospective Studies;
Survival Rate;
Urinary Bladder;
Urinary Tract*
- From:Korean Journal of Urology
1997;38(6):615-620
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The prognostic significance of vascular (blood and lymphatic vessels) invasion was evaluated in a retrospective review of 27 patients with upper urinary tract transitional cell carcinoma from January 1985 to December 1993, who underwent a nephroureterectomy with bladder cuff resection. Vascular invasion was found in 10 patients (37%). The incidence of vascular invasion was well correlated with tumor grade and stage. The incidence of postoperative metastases was significantly higher in the patients with (70%) than without (17.6%) vascular invasion (p<0.05). The survival rate of the patients with vascular invasion was significantly lower than in those without vascular invasion (p<0.01). In multivariate Cox`s regressional analysis the prognostic value of vascular invasion was independent of tumor grade and stage. These results indicate that vascular invasion should predict a more unfavorable outcome in patients with upper urinary tract transitional cell carcinoma as an independent morphological indicator.
