Analysis of the correlation between serum uric acid levels and thyroid hormones among hospitalized elderly gout patients
10.3760/cma.j.issn.0254-9026.2022.03.009
- VernacularTitle:老年痛风患者血尿酸水平与亚临床甲状腺功能减退症关系研究
- Author:
Xiaocui CHENG
1
;
Linling SONG
;
Mingzhen LI
;
Xiuling NIE
;
Jing ZHANG
;
Qiaoyun SUN
Author Information
1. 国家卫生健康委员会激素与发育重点实验室（天津医科大学） 天津市代谢性疾病重点实验室 天津医科大学朱宪彝纪念医院内分泌研究所痛风科 300134
- Keywords:
Gout;
Subclinical hypothyroidism;
Metabolic syndrome X
- From:
Chinese Journal of Geriatrics
2022;41(3):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum uric acid levels and thyroid hormones in hospitalized elderly gout patients.Methods:A total of 646 hospitalized gout patients, including 616 males and 30 females, aged(68.8±5.1)years, who were hospitalized at the Department of Gout, Chu Hsien-I Memorial Hospital from April 2014 to December 2019, were retrospectively analyzed.Clinical information was collected and relevant biochemical tests were conducted.Serum uric acid (SUA)levels were divided into quartiles and their associations with thyroid hormone levels were analyzed.Results:With the increase of SUA, body mass index, the prevalence of obesity, the prevalence of dyslipidemia, and the prevalence of fatty liver, the number of involved joints, cholesterol, low-density lipoprotein cholesterol, triacylglycerol, and homeostasis model assessment trended upward significantly( P<0.05); FUA showed a downward trend( F=9.42, P>0.05). The prevalence of subclinical hypothyroidism in older patients was 11.3%(73 cases). With the increase of SUA, the prevalence of subclinical hypothyroidism and free triiodothyronine levels showed an upward trend, whereas free thyroxine levels showed a downward trend( P<0.01). Conclusions:In elderly gout patients, the prevalence of subclinical hypothyroidism increases with SUA levels.Hyperuricemia and multiple metabolic disorders are independent risk factors for subclinical hypothyroidism in these patients.
