Research progress on the bidirectional relationship between sleep disorders and Parkinson's disease
10.3760/cma.j.issn.0254-9026.2022.02.019
- VernacularTitle:睡眠障碍与帕金森病双向关系的研究进展
- Author:
Yuhao YUAN
1
;
Yan XU
Author Information
1. 华中科技大学同济医学院附属协和医院神经内科，武汉 430022
- Keywords:
Parkinson's disease;
Sleep disorders;
Alpha-synuclein;
Tau proteins
- From:
Chinese Journal of Geriatrics
2022;41(2):220-224
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a progressive neurodegenerative disorder that tends to occur in the elderly.Its clinical manifestations mainly include motor symptoms and non-motor symptoms, with sleep disorders among common non-motor symptoms of PD.The latest lines of evidence show that sleep disorders are not only clinical manifestations of neurodegenerative diseases, but also an important risk factor for the development and progression of neurodegenerative diseases.There is a bidirectional relationship between sleep disorders and neurodegenerative diseases, including PD.The possible mechanisms include accelerated α-synuclein pathology, deposition of Tau protein, inhibition of the glymphatic system, neuroinflammation and changes in the circadian rhythm system.In this article, we review research progress on the bidirectional relationship between sleep disorders and PD, related mechanisms, and the outlook on the treatment of PD through the management of sleep disorders.
