Study on the contrast-enhanced ultrasound characteristics of unstable carotid plaques and their correlation with histopathological findings in elderly patients
10.3760/cma.j.issn.0254-9026.2022.02.005
- VernacularTitle:老年患者颈动脉不稳定性斑块超声造影的特点及其病理相关性研究
- Author:
Xianpu JI
1
;
Na MA
;
Youjing SUN
;
Siyu WANG
;
Yuewei ZHANG
;
Mengpu LI
;
Shuming ZHANG
;
Junhong REN
Author Information
1. 北京医院超声科 国家老年医学中心 中国医学科学院老年医学研究院 100073
- Keywords:
Carotid artery;
Ultrasonography;
Angiography
- From:
Chinese Journal of Geriatrics
2022;41(2):147-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the imaging characteristics on contrast-enhanced ultrasound(CEUS)of carotid plaque instability and their correlation with histopathological changes in elderly patients.Methods:Twenty-three patients undergone carotid endarterectomy(CEA)at the Department of Neurosurgery of Beijing Hospital from June 2018 to November 2020 were retrospectively enrolled, including 27 males and 5 females, aging from 60 to 87(68.1±6.3)years.They were diagnosed with moderate to severe carotid artery stenosis(50%-99%)based on digital subtraction angiography(DSA).Carotid artery CEUS was conducted before surgery, and HE staining and CD34 immunohistochemical staining were used to record histopathological scores and microvessel density(MVD)counts.Results:The mean pathological score and MVD count were 2.46±0.66 and 37.17±12.88 for 32 cases with hypoechoic patterns, 22.42±0.55 and 38.06±13.66 for 18 cases with mixed echo patterns, and 2.75±0.35 and 23.50±9.192 for 2 cases with strong echo patterns, respectively.CEUS grading was positively correlated with histopathology score and MVD count( r=0.53、0.76, all P<0.01). Conclusions:Low echo and mixed echo plaques are more unstable than strong echo plaques.CEUS can be used to comprehensively assess the vulnerability of atherosclerotic plaques and to decide the optimal surgical time for patients with carotid atherosclerotic plaque stenosis.
