Diffuse neurofibrillary tangles with calcification
10.3760/cma.j.issn.0254-9026.2021.12.024
- VernacularTitle:伴钙化的弥散性神经原纤维缠结病
- Author:
Feng FENG
1
;
Mingwei ZHU
;
Luning WANG
Author Information
1. 解放军总医院第一医学中心神经内科，北京 100853
- Keywords:
Diffuse neurofibrillary tangles with calcification;
Clinical characteristics;
Pathological changes;
Diagnosis
- From:
Chinese Journal of Geriatrics
2021;40(12):1589-1591
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse neurofibrillary tangles with calcification(DNTC)is a rare neurodegenerative disease and belongs to the category of tauopathies.The main characteristics of DNTC include presenile dementia, symmetrical bilateral calcification in the basal ganglia and cerebral dentate nuclei, and bilateral atrophy of the temporal lobes.At present, the majority of reported cases with DNTC were from Japan, with only a few cases from other countries.Although DNTC is a pathological diagnosis based on autopsy, ante-mortem diagnosis for DNTC can be achieved based on clinical features and presentation of brain tau protein shown on positron emission computed tomography.The clinical characteristics, pathological changes and diagnosis criteria of DNTC are reviewed in this paper.
