The change in serum fibroblast growth factor 21 level and its correlation with liver functions in elderly patients with hepatitis B virus-related cirrhosis
10.3760/cma.j.issn.0254-9026.2021.12.013
- VernacularTitle:老年乙型肝炎病毒相关肝硬化患者血清成纤维细胞生长因子21水平的变化及其与肝功能的相关性
- Author:
Xu CHEN
1
;
Xiaoou LI
;
Jiali MA
;
Yuling ZHOU
;
Caihong DENG
;
Lingling HE
;
Ping LI
Author Information
1. 北京地坛医院消化内科 100015
- Keywords:
Liver cirrhosis;
Hepatitis B, chronic;
Fibroblast growth factors
- From:
Chinese Journal of Geriatrics
2021;40(12):1537-1540
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the change in serum fibroblast growth factor 21(FGF21)level and its correlation with liver functions in elderly patients with hepatitis B virus(HBV)-related cirrhosis.Methods:A total of 150 elderly patients with HBV infection admitted to Beijing Ditan Hospital and China-Japan Friendship Hospital from January 2019 to December 2020 were selected and divided into chronic hepatitis B(CHB)group(n=70)and HBV-related cirrhosis group(n=80). Healthy subjects were selected as the control group(n=50). Serum FGF21 was determined by ELISA method.Clinical data, clinical laboratory indicators and FGF21 as a core parameter of this study were collected and compared among control group, CHB group, HBV-related cirrhosis group.The correlations of FGF21 level with several liver function indexes were analyzed by Pearson correlation analysis.Results:The levels of total bilirubin(TBil)and total biliary acid(TBA)were significantly higher in HBV-related cirrhosis group than in CHB group.The levels of aspartate transaminase(AST), alanine transaminase(ALT), glutamyl transpeptadase(GGT), serum albumin, cholinesterase, FGF21 and HBV-DNA were significantly lower in HBV-related cirrhosis group than in CHB group(all P<0.05). The levels of serum FGF21 were(108.6 ± 7.3)ng/L, (92.5 ± 7.6)ng/L and(75.8 ± 6.3)ng/L in Child-Pugh A, B and C patients, respectively.The level of FGF21 was statistically significantly decreased with the increase of Child-Pugh grading( F=18.290, P=0.000). Serum FGF21 level was positively correlated with AST, ALT, TBil, cholin-esterase and albumin levels( r=0.652, 0.579, 0.609, 0.558, 0.613, all P<0.05). Conclusions:The level of serum FGF21 is significantly decreased in elderly patients with HBV-related cirrhosis, and is positively correlated with liver function indexes.
