Research progress on drug resistance mechanism and treatment of Stenotrophomonas maltophilia
10.3760/cma.j.issn.1674-2397.2022.01.012
- VernacularTitle:嗜麦芽窄食单胞菌的耐药机制及治疗研究进展
- Author:
Dayan ZHANG
1
;
Gang YANG
;
Zhichu REN
;
Xiang LI
;
Lei ZHA
Author Information
1. 皖南医学院研究生学院，芜湖 241000
- Keywords:
Stenotrophomonas maltophilia;
Antimicrobial resistance mechanism;
Treatment strategy;
Multi-drug resistance
- From:
Chinese Journal of Clinical Infectious Diseases
2022;15(1):61-70
- CountryChina
- Language:Chinese
-
Abstract:
Stenotrophomonas maltophilia is a gram-negative bacillus which widely exists in natural and hospital environment, and it is also one of the common opportunistic pathogens in clinical settings. The virulence and pathogenicity of Stenotrophomonas maltophilia are weak, however, due to resistance to a variety of antibacterial drugs, it can cause bloodstream infections or pneumonia in immunocompromised or critically ill patients, leading to poor prognosis. Moreover, the inherent drug resistance and increasing acquired drug resistance may make the treatment of the first line antibiotics, like trimethoprim-sulfamethoxazole or quinolone ineffective. Therefore, it is important to understand the drug resistance mechanism and the main countermeasures for it. In this article, the research progress on drug resistance mechanism and treatment for Stenotrophomonas maltophilia are reviewed.
