Research progress on HIV latency-reversing agents and its mechanism

VernacularTitle:HIV潜伏感染激活剂及其作用机制研究进展
Author: Zhikai WAN ¹ ; Biao ZHU
Author Information

1. 浙江大学医学院附属第一医院感染病科　传染病诊治国家重点实验室　感染性疾病诊治协同创新中心　国家临床医学研究中心，杭州　310003
Keywords: HIV; HIV latent reservoirs; Shock and kill; HIV latency-reversing agents; Functional cure
From: Chinese Journal of Clinical Infectious Diseases 2021;14(6):460-467,474
CountryChina
Language:Chinese
Abstract: Human immunodeficiency virus (HIV) infection causes severe systemic immune system damage and ultimately leads to patient death. Despite the success of anti-retroviral therapy (ART), which can effectively supress viral replication, there is currently no cure for HIV infection, which requires lifelong treatment. Due to the presence of HIV latent reservoir, the virus persists during antiretroviral treatment. "Shock and Kill" is currently one of the most recognized strategies for removing HIV latent reservoir. The solution is mainly to reactivate viral transcription by using latency-reversing agents (LRAs), which triggers cell lysis or immune-mediated clearance to kill the reactivated HIV infected cells and achieve functional cure. This article gives an overview of current research progress on HIV LRAs and their mechanism of action.