BRICS report of 2020: The bacterial composition and antimicrobial resistance profile of clinical isolates from bloodstream infections in China
- VernacularTitle:2020年全国血流感染细菌耐药监测(BRICS)报告
- Author:
Yunbo CHEN
1
;
Jinru JI
;
Chaoqun YING
;
Zhiying LIU
;
Qing YANG
;
Haishen KONG
;
Yuanyuan DAI
;
Jiliang WANG
;
Haifeng MAO
;
Hui DING
;
Yongyun LIU
;
Yizheng ZHOU
;
Hong LU
;
Youdong YIN
;
Yan JIN
;
Hongyun XU
;
Lixia ZHANG
;
Lu WANG
;
Haixin DONG
;
Zhenghai YANG
;
Fenghong CHEN
;
Donghong HUANG
;
Guolin LIAO
;
Pengpeng TIAN
;
Dan LIU
;
Yan GENG
;
Sijin MAN
;
Baohua ZHANG
;
Ying HUANG
;
Liang GUO
;
Junmin CAO
;
Beiqing GU
;
Yanhong LI
;
Hongxia HU
;
Liang LUAN
;
Shuyan HU
;
Lin ZHENG
;
Aiyun LI
;
Rong XU
;
Kunpeng LIANG
;
Zhuo LI
;
Donghua LIU
;
Bo QUAN
;
Qiang LIU
;
Jilu SHEN
;
Yiqun LIAO
;
Hai CHEN
;
Qingqing BAI
;
Xiusan XIA
;
Shifu WANG
;
Jinhua LIANG
;
Liping ZHANG
;
Yinqiao DONG
;
Xiaoyan QI
;
Jianzhong WANG
;
Xuefei HU
;
Xiaoping YAN
;
Dengyan QIAO
;
Ling MENG
;
Yonghong XIAO
Author Information
- Keywords: Gram-positive bacteria; Gram-negtive bacteria; Drug resistance; Bacterial; Bloodstream infection; National scale; Resistance surveillance
- From: Chinese Journal of Clinical Infectious Diseases 2021;14(6):413-426
- CountryChina
- Language:Chinese
- Abstract: Objective:To investigate the bacterial composition and antimicrobial resistance profile of clinical isolates from bloodstream infections in China.Methods:The clinical bacterial strains isolated from blood culture were collected during January 2020 to December 2020 in member hospitals of Blood Bacterial Resistant Investigation Collaborative System (BRICS). Antibiotic susceptibility tests were conducted by agar dilution or broth dilution methods recommended by Clinical Laboratory Standards Institute(CLSI, USA). WHONET 5.6 was used to analyze data.Results:During the study period, 10 043 bacterial strains were collected from 54 hospitals, of which 2 664 (26.5%) were Gram-positive bacteria and 7 379 (73.5%) were Gram-negative bacteria. The top 10 bacterial species were Escherichia coli (38.6%), Klebsiella pneumoniae (18.4%), Staphylococcus aureus (9.9%), coagulase-negative Staphylococci (7.5%), Pseudomonas aeruginosa (3.9%), Enterococcus faecium (3.3%), Enterobacter cloacae (2.8%), Enterococcus faecalis (2.6%), Acinetobacter baumannii (2.4%) and Klebsiella spp (1.8%). The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus aureus were 27.6% and 74.4%, respectively. No glycopeptide- and daptomycin-resistant Staphylococci were detected. More than 95% of Staphylococcus aureus were sensitive to rifampicin and SMZco. No vancomycin-resistant Enterococci strains were detected. Extended spectrum β-lactamase (ESBL) producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis were 48.4%, 23.6% and 36.1%, respectively. The prevalence rates of carbapenem-resistance in Escherichia coli and Klebsiella pneumoniae were 2.3% and 16.1%, respectively; 9.6% of carbapenem-resistant Klebsiella pneumoniae strains were resistant to ceftazidime/avibactam combination. The prevalence rate of carbapenem-resistance in Acinetobacter baumannii was 60.0%, while polymyxin and tigecycline showed good activity against Acinetobacter baumannii. The prevalence rate of carbapenem-resistance of Pseudomonas aeruginosa was 23.2%. Conclusions:The surveillance results in 2020 showed that the main pathogens of bloodstream infection in China were gram-negative bacteria, while Escherichia coli was the most common pathogen, and ESBL-producing strains declined while carbapenem-resistant Klebsiella pneumoniae kept on high level. The proportion and the prevalence of carbapenem-resistant Pseudomonas aeruginosa were on the rise slowly. On the other side, the MRSA incidence got lower in China, while the overall prevalence of vancomycin-resistant Enterococci was low.
