NAFLD fibrosis score is associated with high-risk coronary plaque in patients with NAFLD
10.3760/cma.j.cn115624-20210527-00297
- VernacularTitle:脂肪肝纤维化评分系统在非酒精性脂肪性肝病人群高风险冠状动脉斑块预测中的价值
- Author:
Hongmei LIN
1
;
Liqing WANG
;
Li QUAN
;
Miaoxia LIN
;
Jie QIN
;
Chao YU
Author Information
1. 中山大学附属第三医院健康管理中心，广州 510630
- Keywords:
Atherosclerosis;
Coronary artery disease;
Non-alcoholic fatty liver disease;
Non-invasive fibrosis score
- From:
Chinese Journal of Health Management
2022;16(2):105-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the possible role of non-invasive fibrosis scoring systems for detecting high-risk plaque among patients with non-alcoholic fatty liver disease (NAFLD).Methods:A total of 477 consecutive asymptomatic subjects underwent a health checkup including coronary computed tomography angiography (CTA) and abdominal ultrasonography. Fatty liver was evaluated using ultrasonography, and the NAFLD fibrosis score (NFS) was calculated. Coronary stenosis and plaque were evaluated using coronary CTA.Results:Of the study population, 223 had NAFLD. Among the NAFLD patients, high-risk coronary plaque was more frequent in patients with high or intermediate NFS than those with low NFS (62.5% versus 24.0%, P<0.001). The adjusted odds ratio with 95% confidence interval of high-risk plaque was 3.24 (1.11-9.40) for the highest versus lowest quartile of NFS ( P=0.016). Among those without NAFLD, NFS was not associated with high-risk coronary plaque (C-statistic with NFS versus without NFS, 0.766 versus 0.764, P=0.715). Adding NFS to the traditional cardiovascular disease (CVD) risk model increased the C-statistics by 0.679 to 0.739 ( P=0.031). Conclusions:There was an independent association of NFS with high-risk coronary plaque in patients with NAFLD, suggesting its potential use to optimize management of patients with NAFLD.
