Application of molecular imaging in chimeric antigen receptor T cell therapy
10.3760/cma.j.cn321828-20201026-00390
- VernacularTitle:分子影像技术在嵌合抗原受体T细胞疗法中的应用
- Author:
Qiong WU
1
;
Yan WANG
;
Min YANG
Author Information
1. 国家卫生健康委员会核医学重点实验室、江苏省分子核医学重点实验室、江苏省原子医学研究所，无锡 214063
- Keywords:
Immunotherapy;
Receptors, antigen, T-Cell;
Molecular imaging;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2022;42(5):308-312
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor T cell (CAR-T) therapy, a novel immunotherapy, shows great potential in the treatment of hematological tumors to conventional therapies. Great progress has been made over the past few decades in the treatment of relapsed/refractory acute/chronic lymphocytic leukemia. However, due to the lack of real-time monitoring methods, it is impossible to predict and assess the therapeutic effect during the treatment of blood tumors, and we cannot learn more about the complications and risks. Many challenges exist in the clinical transformation of CAR-T therapy. As a non-invasive method, molecular imaging shows promise on real-time visualization of the biological behavior of CAR-T in vivo. Tracking CAR-T by directly labeling or indirectly evaluation by reporter gene methods has achieved breakthroughs. This article reviews the current situation of monitoring systems of CAR-T therapy and future expectations for each of the methods presented.
