An Experimental Model of Isolated Lung Block for Evaluation of Pulmonary Preservation after Ischemia.
- Author:
Sook Whan SUNG
1
;
Cheong LIM
;
Young Tae KIM
;
Jong Ho PARK
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Lung preservation;
Transplantation
- MeSH:
Heart Transplantation;
Humans;
Ischemia*;
Kidney;
Korea;
Liver;
Lung Transplantation;
Lung*;
Models, Theoretical*;
Organ Transplantation;
Reperfusion Injury;
Research Personnel;
Tissue Donors;
Transplantation;
Transplants
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1997;30(6):573-579
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
During the last 30 years, major organ transplantation has become popular, even in Korea, such as kidney, liver, etc. After the successful clinical cardiac transplantation in Korea, many cases of cardiac transplantation are being performed in some centers. But lung transplantation has a lot of obstacles, especially donor shortage and decreased tolerability of the lung to ischemia-reperfusion injury. Usually it was considered that the maximum safety margin of ischemic time in lung transplantation was about 4 to 6 hours. So, many investigators have tried to develop better preservation methods and experimental model for evaluation of effectiveness in those various methods. But most of those methods had several drawbacks in clinical and experimental settings. So we developed an easily-controllable, reliable, and inexpensive experimental model of isolated rabbit lung block. Using these model, we evaluated its effectiveness and reliability for the experiment of ischemia-reperfusion injury in lung transplantation.
