Primary study of motion correction effect on myocardial blood flow quantitative imaging with CZT SPECT
10.3760/cma.j.cn321828-20201101-00398
- VernacularTitle:移动校正对CZT SPECT心肌血流定量显像影响的初步研究
- Author:
Zekun PANG
1
;
Jiao WANG
;
Yue CHEN
;
Xiaojie WANG
;
Shuai LI
;
Jianming LI
Author Information
1. 天津医科大学心血管病临床学院、泰达国际心血管病医院核医学科，天津 300457
- Keywords:
Myocardial perfusion imaging;
Tomography, emission-computed, single-photon;
Tellurium;
Zine;
Cadmium;
Image processing, computer-assisted
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2022;42(5):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of motion correction (MC) on the calculated values of myocardial blood flow (MBF) and myocardial flow reserve (MFR) based on cadmium-zinc-telluride SPECT (CZT SPECT) images.Methods:Twenty-eight consecutive patients (10 males, 18 females, age: (60.75±11.62) years) with suspected or known coronary artery disease who underwent myocardial perfusion imaging (MPI) with dynamic CZT SPECT between June 2019 and August 2019 in TEDA International Cardiovascular Hospital were retrospectively analyzed. The MBF and MFR during rest imaging and stress imaging were quantitatively analyzed. Corridor 4DM software was used to calculate the stress MBF (sMBF) and MFR of the coronary artery branches and left ventricular (LV) before and after MC. The paired t test and Pearson correlation were used for data analysis. Results:The sMBF and MFR of LV before MC were (0.82±0.49) ml·min -1·g -1 and 1.69±0.68 respectively. After MC the two parameters increased to (1.05±0.64) ml·min -1·g -1 and 2.12±0.77 respectively ( t values: -4.87, -6.01, both P<0.001). The sMBF and MFR in left anterior descending (LAD), left circumflex (LCX), right coronary artery (RCA) and LV before MC were correlated with those after MC ( r values: 0.69-0.96, all P<0.001). If MFR <2.0 was used as the reference of impaired MFR, data before MC showed 19 patients (67.9%, 19/28) had impaired MFR, while 13 patients (46.4%, 13/28) had impaired MFR based on MFR values after MC. Conclusion:For MPI quantitative imaging with CZT SPECT, the calculated values of sMBF and MFR after MC is higher than those before MC, suggesting that MC is helpful to reduce the false positive results which may be caused by the " creep" effect of the heart.
