Research progress in the role of TRPV channel-induced Ca 2+ signal in osteoclast differentiation and bone resorption
10.3760/cma.j.cn121113-20210430-00331
- VernacularTitle:TRPV通道诱导的Ca 2+信号在破骨细胞分化和骨吸收中的作用研究进展
- Author:
Shuwei GONG
1
;
Jianxiong MA
;
Xinlong MA
Author Information
1. 天津中医药大学研究生院，天津 301617
- From:
Chinese Journal of Orthopaedics
2022;42(10):668-674
- CountryChina
- Language:Chinese
-
Abstract:
Osteoclast is a type of multinuclear giant cell, which plays a role in bone resorption in the homeostasis of bone mass. Excessive bone resorption leads to osteoporosis and other diseases characterized by decreased bone mass. Ca 2+ metabolism plays an important role as a second messenger in the differentiation, migration, fusion and bone resorption of osteoclast. The transient receptor potential vanilloid (TRPV) ion channel is expressed in a variety of cells, including osteoclast. Current studies have found that the TRPV ion channel can participate in the production and bone resorption function of osteoclast by increasing intracellular Ca 2+ concentration and calcium oscillations. This article reviews the relationship between the TRPV ion channel and the changes of Ca 2+ concentration and the potential mechanisms involved in osteoclast activity, so as to provide a reference for further research on diseases characterized by abnormally increased activation of osteoclast in the future.
