Research progress on mechanism of intestinal mucosal mechanical barrier injury associated with severe acute pancreatitis

VernacularTitle:重症急性胰腺炎相关肠黏膜机械屏障损伤机制的研究进展
Author: Shangxian MA ¹ ; Fengxian WEI ; Jianxiong WANG ; Hongyang DENG ; Xiaodong XU
Author Information

1. 兰州大学第二医院普通外科，兰州　730000
Keywords: Pancreatitis; Intestinal mucosa; Molecular mechanism
From: Chinese Journal of Hepatobiliary Surgery 2022;28(4):313-317
CountryChina
Language:Chinese
Abstract: Severe acute pancreatitis (SAP) is closely related to intestinal mucosal barrier dysfunction, in which intestinal epithelial mechanical barrier injury is the structural basis of SAP-related intestinal mucosal dysfunction. Among the molecular mechanisms of injury factors, inflammatory mediators and cytokines, produced by SAP waterfall inflammation, are the main factors of intestinal mucosal barrier injury. This article briefly describes the effects of SAP on intestinal mechanical barrier injury and its molecular mechanism in order to provide ideas for the treatment of SAP.