Research status on the role of exosomes in the tumor microenvironment of hepatocellular carcinoma

VernacularTitle:外泌体在肝细胞癌肿瘤微环境中作用的研究进展
Author: Kunli YIN ¹ ; Ming LI ; Xufu WEI ; Rui LIAO
Author Information

1. 重庆医科大学附属第一医院肝胆外科，重庆　400016
Keywords: Exosome; Hepatocellular carcinoma; Tumor microenvironment; Tumor detection; Tumor treatment; Prognosis
From: Chinese Journal of Hepatobiliary Surgery 2022;28(4):305-309
CountryChina
Language:Chinese
Abstract: The tumor microenvironment of hepatocellular carcinoma (HCC) is complex, leading to the high heterogeneity, occurrence and development of HCC. Exosomes are one of the most important components of HCC tumor microenvironment. Exosomes are membranous vesicles with the diameter about 40~160 nm, consisting with protein, nucleic acid and other substances, and can carry out signal transmission between cells. The information regulation of HCC-derived exosomes in the tumor microenvironment has a significant impact on the malignant biological behavior of HCC. In recent years, studies on the role of exosomes in the detection, treatment and prognosis of HCC have been made in-depth. This review focused on the role of exosomes in the biological process of HCC microenvironment, and discusses the research progress of exosomes in the HCC angiogenesis, metastasis, epithelial-mesenchymal transformation and immune regulation and so on.