Factors influencing recurrence and survival after resection of intrahepatic cholangiocarcinoma
10.3760/cma.j.cn113884-20211009-00328
- VernacularTitle:肝内胆管细胞癌切除术后复发与生存时间的影响因素分析
- Author:
Peng LI
1
;
Ruizhao QI
;
Lingxiang YU
;
Hui REN
;
Qian CAO
;
Guanghao DIAO
;
Muyi YANG
;
Dexi ZHAO
;
Yu ZHANG
;
Zhaohai WANG
Author Information
1. 山东省潍坊医学院，潍坊 261053
- Keywords:
Bile duct neoplasms;
Cholangiocarcinoma;
Hepatectomy;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(4):270-274
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the factors influencing prognosis of intrahepatic cholangiocarcinoma (ICC) after surgical resection.Methods:The clinical data of patients diagnosed with ICC and who underwent surgical resection from December 2015 to December 2019 at the Fifth Medical Center of PLA General Hospital were retrospectively analyzed. Of 39 patients who were included in this study, there were 23 males and 16 females, with age of (54.1±7.2) years old. The body mass index, hepatitis B virus infection status, tumor diameter, degree of differentiation, microvascular tumor thrombus, lymph node metastasis, and serum levels of carbohydrate antigen 19-9 (CA19-9) were analyzed as risk factors affecting postoperative recurrence and survival.Results:The median times to recurrence were significantly better in patients with a tumour length <5 cm (11 vs. 5 months), patients without microvascular tumor thrombus (54 vs. 6 months) and patients without lymph node metastasis (8 vs. 5 months) (all P<0.05). The median survival of patients with CA19-9≥100 U/ml was significantly shorter than that of patients with CA19-9<100 U/ml, (9 vs. 27 months, P<0.05). Tumor diameter>5 cm, microvascular tumor thrombus, lymph node metastasis, and CA19-9 ≥100 U/ml are risk factors affecting the recurrence time after ICC resection, CA19-9 ≥100 U/ml is a risk factor affecting survival time after ICC resection. Conclusion:Tumor diameter, microvascular tumor thrombus, lymph node metastasis and CA19-9 can be used to estimate the risk of ICC recurrence, and CA19-9 level can be used to estimate postoperative survival of ICC patients after resection.
