Correlation of mucin1 and Ki67 expression with clinical pathological characteristics and prognosis of intrahepatic cholangiocarcinoma
10.3760/cma.j.cn113884-20210607-00192
- VernacularTitle:黏蛋白1、Ki67的表达与肝内胆管细胞癌患者临床病理特征及预后的关系
- Author:
Zeyuan QIANG
1
;
Shuai JIN
;
Cao YAN
;
Zhen LI
;
Peigang NING
;
Haibo YU
Author Information
1. 河南大学人民医院（河南省人民医院）肝胆胰腺外科，郑州 450003
- Keywords:
Cholangiocarcinoma;
Prognosis;
Ki-67 antigen;
Mucin1
- From:
Chinese Journal of Hepatobiliary Surgery
2022;28(1):33-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of mucin 1 (MUC1) and Ki67 in intrahepatic cholangiocarcinoma (ICC), and to explore the correlations between the expression of MUC1 and Ki67 and the clinicopathological features and prognosis of ICC patients.Methods:Clinical data of 398 patients with ICC admitted to Henan Provincial People's Hospital from January 2013 to March 2020 were retrospectively analyzed. A total of 104 patients were included in this study, including 67 males and 37 females, aged (56.6±9.3) years. Immunohistochemistry was used to detect the expression of MUC1 and Ki67 in cancer tissues. Univariate and multivariate Cox regression analysis were used to study the prognostic factors of ICC patients.Results:The expression of MUC1 was low in 65 patients and high in 39 patients. Ki67 expression was low in 52 patients and high in 52 patients. High expression of MUC1 was correlated with lymph node metastasis ( P<0.05), while high expression of Ki67 was correlated with tumor nodes number, lymph node metastasis and vascular invasion (all P<0.05). Multivariate analysis showed that ICC patients with high MUC1 expression ( HR=2.321, 95% CI: 1.420-3.792, P<0.001) and high Ki67 expression ( HR=2.012, 95% CI: 1.247-3.247, P=0.004) showed a poor prognosis after hepatectomy. ICC patients with high MUC1 expression ( HR=1.664, 95% CI: 1.058-2.618, P=0.028) and high Ki67 expression ( HR=1.883, 95% CI: 1.168-3.035, P=0.009) had a poor prognosis after hepatectomy. Conclusion:High expression of MUC1 and Ki67 is correlated with tumor growth and metastasis. MUC1 and Ki67 are independent risk factors for prognosis of ICC patients after hepatectomy.
