Molecular subtyping of cholangiocarcinoma and its potential clinical application

VernacularTitle:肝内胆管癌的分子分型及其临床应用研究进展
Author: Jingshu TONG ¹ ; Yeming ZHOU ; Caide LU ; Changjiang LU ; Jing HUANG
Author Information

1. 宁波大学医学院，宁波　315211
Keywords: Cholangiocarcinoma; Molecular typing; Clinical application; Progress
From: Chinese Journal of Hepatobiliary Surgery 2021;27(12):954-957
CountryChina
Language:Chinese
Abstract: Intrahepatic cholangiocarcinoma (ICC) has a high degree malignancy, and its incidence has gradually increased in recent years. Surgery is still the only curative treatment for ICC to achieve long-term survival, but its onset is hidden, and most patients have lost the opportunity of operation when they are diagnosed. ICC shows significant heterogeneity. With the development of the second generation sequencing technology, the tumor patterns of ICC, such as DNA, RNA, epigenetic, protein, microenvironment and so on, have been gradually discovered. The purpose of this article is to review the research progress of molecular typing and clinical application of ICC in recent years.