Research progress on the role of astrocytes in radiation-induced brain injury
10.3760/cma.j.cn113030-20201026-00511
- VernacularTitle:星形胶质细胞在放射性脑损伤中作用研究进展
- Author:
Wenjun ZHU
1
;
Xiaohong PENG
;
Xiaoyu LI
;
Na LUO
;
Wenhua TANG
;
Min FU
;
Yuanyuan ZHANG
;
Feng YANG
;
Haiting ZHOU
;
Su WEN
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤科，武汉 430030
- Keywords:
Radiation-induced brain injury;
Astrocyte;
Neuroinflammation;
Vascular injury;
Neuron damage
- From:
Chinese Journal of Radiation Oncology
2022;31(6):589-593
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced brain injury (RBI) is one of the complications after radiotherapy for head and neck malignant tumors, which seriously affects the quality of life of patients. The pathophysiological mechanism of RBI is not completely clear. Current studies suggest that it is involved in a variety of cells in the central nervous system (CNS), whereas astrocyte, as the largest number of glial cells in the CNS, plays an important role in maintaining the CNS homeostasis and responding to CNS injury. In this article, the role of astrocytes in RBI was reviewed.
