The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats.
10.14730/aaps.2016.22.3.129
- Author:
Da Han KIM
1
;
You Seong SONG
;
Seung Yong SONG
;
Chung Hun KIM
Author Information
1. Yonsei E1 Plastic Surgery Clinic, Anyang, Korea.
- Publication Type:Original Article
- Keywords:
Breast implants;
Contracture;
Rats;
Vascular endothelial growth factor
- MeSH:
Animals;
Blood Vessels;
Breast Implants;
Contracture;
Female;
Humans;
Ischemia;
Rats*;
Rats, Sprague-Dawley;
Silicon*;
Silicones*;
Tromethamine;
Vascular Endothelial Growth Factor A*
- From:Archives of Aesthetic Plastic Surgery
2016;22(3):129-134
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture. METHODS: We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 µg/0.1 cc, (3) VEGF 150 µg/0.1 cc during placement of the implant, or (4) VEGF 150 µg/0.1 cc and VEGF 300 µg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels. RESULTS: All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman's correlation coefficient, 0.2732; P<0.0001). CONCLUSIONS: A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.
