Analysis of risk factors associated with brain metastasis of limited small cell lung cancer after prophylactic cranial irradiation

VernacularTitle:局限期小细胞肺癌预防性脑照射后脑转移相关危险因素分析
Author: Mingxu LI ¹ ; Songliu HU
Author Information

1. 哈尔滨医科大学附属肿瘤医院放疗科，哈尔滨　150081
Keywords: Neoplasm, small cell lung; Prophylactic cranial irradiation; Brain metastasis; Risk factor
From: Chinese Journal of Radiation Oncology 2022;31(4):395-399
CountryChina
Language:Chinese
Abstract: Small cell lung cancer (SCLC) has the biological characteristics of high recurrence and metastasis. The brain is the common site of SCLC extrapulmonary metastasis. Prophylactic cranial irradiation (PCI) can effectively reduce the incidence of brain metastasis and prolong the overall survival of patients with limited SCLC. Nevertheless, nearly one third of patients develop brain metastases after PCI. This article reviews the risk factors of brain metastasis after PCI, aiming to determine which subgroup of patients with limited SCLC can benefit from PCI and provide reference for the clinical application of PCI.