Preliminary study of stereotactic cardiac radioablation in radiotherapy of ventricular arrhythmia
10.3760/cma.j.cn113030-20211015-00412
- VernacularTitle:立体定向心脏放射消融术用于室性心律失常初探
- Author:
Jing LI
1
;
Qingyong CHEN
;
Guangjun LI
;
Yan LI
;
Yingjie ZHANG
;
Changhu LI
;
Long BAI
;
Renming ZHONG
;
Yinbo HE
;
Sen BAI
;
Qing YANG
;
Feng XU
Author Information
1. 四川大学华西医院肿瘤中心放疗科，成都 610041
- Keywords:
Ventricular arrhythmia/stereotactic cardiac radioablation;
Stereotactic body radiotherapy;
Preliminary study
- From:
Chinese Journal of Radiation Oncology
2022;31(3):260-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To introduce the stereotactic cardiac radioablation (SCRA) based on the stereotactic body radiotherapy (SBRT), and comprehensively evaluate the new approach by short-term effectiveness and safety.Methods:Patients with ventricular arrhythmia (VA) were evaluated and included in this clinical trial, who were immobilized by vacuum bag and performed simulation with 4-dimensional computed tomography (4DCT). In this study, the planning target volume (PTV) was set as the target to design a SBRT plan using volumetric modulated arc therapy (VMAT), which was evaluated by dose parameters such as R 50%, homogeneity index and conformity index, etc. The results of Holter and echocardiography were monitored during the follow-up and compared with the data before treatment. Results:Three subjects with ventricular tachycardia (VT) and one with premature ventricular contraction (PVC) received the same prescription of 25 Gy in a single fraction. The average volume of PTV was 71.4 cm 3(60.3-89.4 cm 3). The average time of beam delivery was 12.0 min (4.5-21.0 min). And the short-term follow-up lasted for an average of 18 weeks (14-25 weeks), which showed significant decrease in both VT and PVC load without complications. Conclusion:This study reports the implementation method of SCRA and proves its short-term effectiveness and safety, but the effects and standards of the key radiotherapy techniques still need to be explored.
