Local recurrence pattern of pT 1-2N 1 breast cancer after modified radical mastectomy—a pooled-analysis of 5442 patients from 12 centers
10.3760/cma.j.cn113030-20211008-00382
- VernacularTitle:改良根治术后pT1-2N1期乳腺癌的局部区域复发部位
- Author:
Xinyuan GUO
1
;
Yujing ZHANG
;
Na ZHANG
;
Yu TANG
;
Xuran ZHAO
;
Hao JING
;
Hui FANG
;
Ge WEN
;
Jing CHENG
;
Mei SHI
;
Qishuai GUO
;
Hongfen WU
;
Xiaohu WANG
;
Changying MA
;
Yexiong LI
;
Hongmei WANG
;
Min LIU
;
Shulian WANG
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京 100021
- Keywords:
Breast neoplasm/modified radical mastectomy;
Breast neoplasm/post-operationradiotherapy;
Locoregional recurrence;
Positive node
- From:
Chinese Journal of Radiation Oncology
2022;31(3):248-252
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze locoregional recurrence (LRR) pattern of patients with pT 1-2N 1 breast cancer after modified radical mastectomy, with and without adjuvant radiotherapy (RT). Methods:A total of 5442 eligible patients with breast cancer from 12 Chinese centers were included. The LRR sites and the effect of RT at different sites on recurrence in patients with and without RT were analyzed. The Kaplan-Meier method was used to calculate the cumulative LRR rate, and the difference was compared by the log-rank test.Results:With a median follow-up time of 63.8 months for the entire cohort, 395 patients developed LRR. The chest wall and supraclavicular fossa were the most common LRR sites, regardless of RT or molecular subtypes. The 5-year chest wall recurrence rates for patients with and without chest wall irradiation were 2.5% and 3.8%( P=0.003); the 5-year supraclavicular lymph nodal recurrence rates for patients with and without supraclavicular fossa irradiation were 1.3% and 4.1%( P<0.001); the 5-year axillary recurrence-free rates for patients with and without axillary irradiation were 0.8% and 1.5%( HR=0.31, 95% CI: 0.04-2.23, P=0.219); and the 5-year internal mammary nodal recurrence-free rates for patients with and without internal mammary nodal irradiation were 0.8% and 1.5%( HR=0.45, 95% CI: 0.11-1.90, P=0.268). Conclusions:The chest wall and supraclavicular fossa are the most common LRR sites of patients with pT 1-2N 1 breast cancer after modified radical mastectomy, which is not affected by adjuvant RT or molecular subtypes. The chest wall and supraclavicular fossa irradiation significantly reduce the risk of recurrence in the corresponding area. However, axillary and internal mammary nodal irradiation has no impact on the risk of recurrence in the corresponding area.
