Meta-analysis of chrono-chemotherapy combined with radiotherapy for locally advanced nasopharyngeal carcinoma
10.3760/cma.j.cn113030-20210531-00211
- VernacularTitle:时辰化疗联合放疗局部晚期鼻咽癌疗效 Meta分析
- Author:
Jianquan YANG
1
;
Wen GUO
;
Jinyi LANG
;
Man LU
Author Information
1. 电子科技大学医学院，成都 610051
- Keywords:
Nasopharyngeal neoplasm/chrono-chemotherapy;
Nasopharyngeal neoplasm/radiotherapy;
Meta-analysis
- From:
Chinese Journal of Radiation Oncology
2022;31(2):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically compare the efficacy and safety of chrono-chemotherapy combined with radiotherapy in patients with locally advanced nasopharyngeal carcinoma.Methods:Seven databases were searched, including the Cochrane Library (Issue 5, 2021), PubMed, Embase, CBM, CNKI, VIP and Wanfang Database. The method ological quality of the eligible studies was evaluated. The Meta-analysis was performed by the Revman 5.3 software.Results:Sixteen studies consisting of 1275 patients were finally included. Among them, 642 patients were treated with chrono-chemotherapy combined with radiotherapy and 633 patients received conventional chemotherapy combined with radiotherapy. Results showed that compared with conventional chemotherapy group, the effective rate was significantly elevated ( OR=1.66, 95% CI: 1.17-2.34, P=0.004), the incidence of leucopenia, thrombocytopenia, gastrointestinal reaction, grade 3-4 oral mucosal reaction and grade 3-4 radiothermitis was significantly reduced (all P<0.001), and the quantity of CD3, CD4 and CD4/CD8 was significantly increased in the chrono-chemotherapy group. Conclusion:Current evidence shows that compared with conventional chemotherapy, chrono-chemotherapy combined with radiotherapy could improve the effective rate, reduce adverse reactions and mitigate the destruction of immune function simultaneously.
