Observation on chromosome aberration of peripheral blood lymphocytes in children with vascular diseases after interventional procedure
10.3760/cma.j.cn112271-20210922-00387
- VernacularTitle:儿童脉管性疾病患者介入手术后外周血淋巴细胞染色体畸变观察
- Author:
Ya MA
1
;
Dianjun HOU
;
Lei GUO
;
Dan SONG
;
Wei ZHU
;
Weiguo LI
;
Xuesong MAO
;
Lianying FANG
;
Zhongwen WANG
Author Information
1. 中国原子能科学研究院，北京 102413
- Keywords:
Ionizing radiation;
Interventional procedure;
Children;
Dicentric chromosome
- From:
Chinese Journal of Radiological Medicine and Protection
2022;42(2):89-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of ionizing radiation on chromosome aberration of peripheral blood lymphocytes in children with vascular interventional procedure.Methods:The chromosome aberration of peripheral blood lymphocytes was analyzed before and after vascular interventional procedure to assess the effect of low-dose ionizing radiation on chromosomes. Peripheral blood (PB) was collected using heparin as an anticoagulant from 26 patients before and after (within 10 minutes) vascular interventional surgery. Informed consent was obtained from the patients′ parents.Results:Dicentric + centric ring (dic+ r) formation increased significantly ( U=647, P<0.01) in peripheral blood lymphocytes of children after interventional operation. No correlation was observed between the rate of dic+ r and the cumulative dose (CD), dose area product (DAP), age, body weight, gender and the estimated effective dose E ( P>0.05). There was no significant difference in dic+ r rate of children between different genders, ages and lesion sites ( P>0.05). The dic+ r rate after interventional operation exceeded 40×10 -3 in 4 of 26 cases with the highest of 95.83×10 -3. Conclusions:The ionizing radiation during children′s vascular interventional procedure might lead to the increase of chromosome aberration of peripheral blood lymphocytes and some children are abnormally sensitive. Great attention should be paid to the justification and radiation protection during interventional procedure for children.
