Analysis of hepatitis B virus infection status in patients with systemic lupus erythematosus
10.3760/cma.j.cn141217-20210823-00336
- VernacularTitle:系统性红斑狼疮患者乙型肝炎病毒感染状态分析
- Author:
Jingjing ZHANG
1
;
Yue JIA
;
Lingfei MO
;
Yanhua WANG
;
Jing LUO
;
Nan HU
;
Lan HE
;
Jing WANG
Author Information
1. 西安交通大学第一附属医院风湿免疫科，西安 710061
- Keywords:
Lupus erythematosus, systemic;
Hepatitis B virus;
Hepatitis B surface antigen;
Hepatitis B antibodies
- From:
Chinese Journal of Rheumatology
2022;26(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of systemic lupus erythematosus (SLE) on the status of hepatitis B virus (HBV) infection, and provide data for clarifying the relationship between autoimmunity and infection.Methods:SLE patients in the department of rheumatology and immunology of the First Affiliated Hospital of Xi'an Jiaotong University from January 2016 to December 2019 were screened. A retrospective case-control study was carried out. SLE patients with positive hepatitis B surface antigen (HBsAg) were gender and age matched with chronic hepatitis B (CHB) in a 1∶4 ratio. Chi-square test was used to compared the positive rates of hepatitis B e antigen (HBeAg) and Paired-Samples t test or Signed rank Wilcoxon test was used to compare the HBV DNA load and HBsAg titer. Results:The positive rate of HBsAg in SLE patients was lower than the prevalence rate of HBsAg in general population in the second Chinese National Hepatitis Seroepidemiological Survey in 2006 [2.2%(27/1 227) vs 7.2%], but the positive rate of HBcAb was not obviously different from that in general population in China [33.9%(416/1 227) vs 34.1%]. Compared with matched CHB patients, the positive rate of HBeAg [37.0%(10/27) vs 58.3%(63/108), χ2=3.94, P=0.047], the HBV DNA load [0(0, 3.7) lg U/ml vs 4.8(2.2, 3.7) lg U/ml, Z=-5.37, P<0.001] and HBsAg titer [(2.0±1.5) lg U/ml vs (3.3±1.1) lg U/ml, t=-4.26, P<0.001] in SLE patients were lower. Conclusion:The HBV infection status of SLE patients is different from that of patients with chronic hepatitis B and the HBV infection is more likely to be controlled.
