A randomized double-blinded placebo-controlled clinical trial of minodronate tablet in postmenopausal Chinese women with osteoporosis
10.3760/cma.j.cn112141-20220220-00108
- VernacularTitle:国产米诺膦酸片治疗绝经后骨质疏松症的随机、双盲、安慰剂对照多中心临床研究
- Author:
Chao PENG
1
;
Rong TIAN
;
Ling LI
;
Yikun ZHU
;
Shuying LI
;
Shandong YE
;
Liang HE
;
Jiapeng NIU
;
Qiu ZHANG
;
Yingfang ZHOU
Author Information
1. 北京大学第一医院妇产科，北京 100034
- Keywords:
Osteoporosis, postmenopausal;
Diphosphonates;
Randomized controlled trial;
Placebos;
Clinical study
- From:
Chinese Journal of Obstetrics and Gynecology
2022;57(5):346-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To verify the efficacy and safety of daily oral minodronate in postmenopausal women with established osteoporosis.Methods:In this randomized, double-blinded, placebo-controlled trial, 262 postmenopausal women were enrolled. Patients were randomized to receive daily oral minodronate 1 mg with supplements of 500 mg calcium and 200 U vitamin D 3 ( n=130) or placebo ( n=132) with daily supplements of 500 mg calcium and 200 U vitamin D 3, for 48 weeks. The primary endpoint was the average bone mineral density (BMD) change in the lumbar vertebrae 48 weeks post-treatment. Secondary outcome measures was the incidence of vertebral fractures. Safety assessments included the rate of adverse events. Results:At the end of 48 weeks treatment, the average BMD change rate from baseline were: full analysis set results: (3.52±4.82)% in the minodronate group and (2.00±5.74)% in the placebo group; per-protocol set results: (3.99±5.05)% in the minodronate group and (2.07±6.20)% in the placebo group; the differences were all significant (all P<0.05). Vertebral fracture occured in 3 patients (2.3%, 3/132) in the placebo group, and 1 case (0.8%, 1/130) in the minodronate group ( P>0.05). The incidence of adverse events was 71.5% (93/130) in the minodronate group and 78.0% (103/132) in the placebo group ( P>0.05). Conclusion:Minodronate is effective and safe in the treatment of postmenopausal osteoporosis without severe side effects.
