Evaluation of cardiac function and systolic dyssynchrony of fetuses exposed to maternal anti-SSA and anti-SSB antibodies using two-dimensional speckle tracking imaging
10.3760/cma.j.cn131148-20210808-00537
- VernacularTitle:二维斑点追踪成像评价抗SSA和抗SSB抗体阳性孕妇胎儿心功能及收缩非同步性
- Author:
Shasha DUAN
1
;
Yong WANG
;
Yaxi WANG
;
Yilu SHI
;
Lu ZHANG
;
Wuping XIAO
;
Xiaoshan ZHANG
Author Information
1. 内蒙古医科大学附属医院超声医学科，呼和浩特 010050
- Keywords:
Two-dimensional speckle tracking imaging;
Anti-SSA antibody;
Fetus;
Cardiac function;
Systolic dyssynchrony
- From:
Chinese Journal of Ultrasonography
2022;31(4):289-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the cardiac function and systolic dyssynchrony of fetuses exposed to maternal autoimmune antibodies (anti-SSA/Ro60, anti-SSA/Ro52 and anti-SSB/La) by using two-dimensional speckle tracking imaging (2D-STI).Methods:A total of 52 pregnant women with singleton pregnancy in the Affiliated Hospital of Inner Mongolia Medical University from July 2018 to November 2020 were selected. Eighteen fetuses of mothers with autoimmune antibodies were enrolled as autoimmune disease (AD) group and 34 fetuses of healthy mothers without antibodies were included as control group. Maternal baseline characteristics, fetoplacental Doppler parameters, and conventional echocardiographic data of two groups were prospectively collected. The systolic global and regional longitudinal strain of left and right ventricles (LV and RV) and the time to peak strain of regional myocardium were measured using 2D-STI. The differences in time to peak strain between the LV free wall and RV free wall (two-chamber dyssynchrony, 2C-DYS) and between the septum and LV free wall (one-chamber dyssynchrony, 1C-DYS) were also calculated.Results:There were no significant differences between the two groups in conventional systolic and diastolic functional parameters for the LV and RV(all P>0.05). The myocardial deformation parameters and 2C-DYS obtained by 2D-STI showed no statistical differences between two groups(all P>0.05). However, 1C-DYS was significantly more prolonged in the AD group than control group[28.50(13.50, 39.25)ms vs 19.50(8.00, 29.25)ms, P=0.042]. Conclusions:LV systolic mechanical dyssynchrony in fetuses of mothers with autoimmune antibodies suggests in-utero subclinical damage of the cardiac conduction system.
