Application of clinical and ultrasound-based model in evaluating the severity of secondary hyperparathyroidism
10.3760/cma.j.cn131148-20210608-00392
- VernacularTitle:临床-超声视觉征象模型评估继发性甲状旁腺功能亢进严重程度的应用研究
- Author:
Wenxin XU
1
;
Xiaoer ZHANG
;
Jinhua LIN
;
Manxia LIN
;
Guangliang HUANG
;
Xiaoyan XIE
;
Ming XU
Author Information
1. 中山大学附属第一医院超声医学科 中山大学超声诊断与介入超声研究所，广州 510080
- Keywords:
Clinical and ultrasound-based model;
Secondary hyperparathyroidism;
Gray-scale ultrasound;
Contrast-enhanced ultrasound;
Intact parathyroid hormone
- From:
Chinese Journal of Ultrasonography
2021;30(12):1052-1057
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the gray-scale ultrasound and contrast-enhanced ultrasound features in secondary hyperparathyroidism (SHPT) to construct a clinical and ultrasound-based model, and to investigate the relationship between this model and serum intact parathyroid hormone(iPTH) level in order to find proper indicators for evaluation of the severity of SHPT.Methods:From February 2016 to March 2021, a total of 59 SHPT patients with 181 parathyroid glands (PTGs) admitted to the First Affiliated Hospital of Sun Yat-Sen University were enrolled. Gray-scale ultrasound and contrast-enhanced ultrasound were performed in every participant. Patients were divided into low-iPTH group ( iPTH<800 ng/L) and high-iPTH group (iPTH≥800 ng/L) according to the serum iPTH level. The characteristics of gray-scale ultrasonic imaging and contrast-enhanced ultrasonic imaging were analyzed by 2 sonographers.Biochemical parameters were collected and combined with ultrasonic characteristics to construct the clinical and ultrasound-based model. The relationship between the model and serum iPTH level was analyzed by multivariate linear regression (stepwise). Independent influencing factors on serum iPTH level was investigated in SHPT patients without iPTH-reducing drugs using history.Results:There were 19 patients in low-iPTH group and 40 patients in high-iPTH group.Serum calcium, serum phosphorus, serum creatinine, PTG number, total PTG volume, blood scores, calcification and cysts scores, CEUS scores (washing-in phase and washing-out phase) were significantly different between two groups(all P<0.05). The multivariate linear regression (stepwise) showed that serum phosphorus, total PTG volume and blood scores were independently related with serum iPTH level (standardized β coefficient were 0.387, 0.254 and 0.242 respectively; all P<0.05). Conclusions:Serum phosphorus, total PTG volume and blood scores are independent influencing factors on serum iPTH level. Ultrasonography combined with clinical parameters can help evaluate the severity of SHPT more accurately.
