Risk factors of bone cement leakage after percutaneous vertebroplasty for osteoporotic vertebral compression fracture
10.3760/cma.j.cn501098-20211218-00670
- VernacularTitle:骨质疏松性椎体压缩骨折行经皮椎体成形术后骨水泥渗漏危险因素分析
- Author:
Yi ZHANG
1
;
Hongwei KOU
;
Guowei SHANG
;
Yanhui JI
;
Tian CHENG
;
Xiangrong CHEN
;
Deming BAO
;
Junjie GUO
;
Fanguo KONG
;
Yuwei LI
;
Chengqi ZHANG
;
Huimin ZHU
;
Jimin PEI
;
Haijiao WANG
;
Hongjian LIU
Author Information
1. 郑州大学第一附属医院骨科，郑州 450002
- Keywords:
Osteoporotic fractures;
Vertebroplasty;
Risk factors;
Bone cements
- From:
Chinese Journal of Trauma
2022;38(5):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of bone cement leakage after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fracture (OVCF).Methods:A multi-center, large-sample, case-control study was carried out to analyze the clinical data of 2 273 OVCF patients (2 689 vertebrae) undergone PVP at four hospitals between May 2018 and October 2021, including 994 males and 1 279 females, with the age of 52-91 years [(69.1±3.1)years]. Of all, 581 patients (604 vertebrae) were allocated to leakage group and 1 692 patients (2 085 vertebrae) to no leakage group according to the occurrence of bone cement leakage. The gender, age, fracture sites, vertebral compression degree, endplate integrity of fractured vertebrae, surgical segments, surgical approaches and bone cement injection volume were recorded. Univariate analysis was used to investigate the correlation between those indicators with bone cement leakage. Multivariate Logistic regression analysis was used to identify the independent risk factors for bone cement leakage.Results:Univariate analysis showed that gender, age, fracture sites, vertebral compression degree, bone cement injection volume were related to bone cement leakage after PVP ( P<0.05 or 0.01), but no correlation was found in the endplate integrity of fractured vertebrae, surgical segments and surgical approaches (all P>0.05). Multivariate Logistic regression analysis showed that fracture sites ( OR=1.68, 95% CI 1.11-2.55, P<0.05), vertebral compression degree more than 40% ( OR=1.98, 95% CI 1.29-3.02, P<0.01), bone cement injection volume greater than or equal to 5.5 ml ( OR=1.55, 95% CI 1.07-2.26, P<0.05) were significantly associated with bone cement leakage after PVP. Conclusion:Thoracic vertebral fracture, vertebral compression degree more than 40% and bone cement injection volume greater than or equal to 5.5 ml are independent risk factors for bone cement leakage after PVP in OVCF.
