Research progress in mechanism of high mobility group box 1 regulating inflammatory response
10.3760/cma.j.cn501098-20211029-00560
- VernacularTitle:高迁移率族蛋白1调控炎症反应机制的研究进展
- Author:
Wei MA
1
;
Xin LIANG
;
Jiaxin LI
;
Shengxiang AO
;
Xue YANG
;
Wanqi TANG
;
Huaping LIANG
;
Xia YANG
Author Information
1. 陆军军医大学大坪医院战伤感染与特需药品研究室，重庆 400042
- Keywords:
High mobility group proteins;
Receptors, immunologic;
Inflammation;
Translational protein modification
- From:
Chinese Journal of Trauma
2022;38(3):283-288
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory reaction dominated by defense response will arise against infection and trauma. As an important proinflammatory cytokine, high mobility group box 1 (HMGB1) is widely expressed in all nuclear cells to mediate the inflammatory response. However, the biological functions of HMGB1 in inflammation vary depending on the type of HMGB1 protein modification and the localization in the cell. HMGB1 protein will be modified as acetylation of lysine residues, methylation of lysine residues, oxidation of cysteine residues, phosphorylation of serine residues, glycosylation of asparagine residues, adenosine diphosphate-ribosylation and lactylation of the protein in the nucleus, migrate from the nucleus to the cytoplasm, and release into the extracellular compartment. Extracellular HMGB1 can bind to receptors for advanced glycation end products (RAGE) and Toll-like receptors, activate cells and regulate inflammatory responses. The authors review the research progress in regulatory mechanism of HMGB1 in inflammation response from aspects of its post-translational modifications, releases, biological roles and binding receptors, hoping to provide theoretical basis for finding the targets of inflammation intervention.
