Research progress of genes related to prognosis of osteosarcoma
10.3760/cma.j.cn101721-20211011-000173
- VernacularTitle:骨肉瘤预后相关基因的研究进展
- Author:
Xiaobo ZHANG
1
;
Guixia SHI
;
Heng CAO
;
Jianlong WANG
Author Information
1. 中南大学湘雅三医院脊柱外科，长沙 410000
- Keywords:
Osteosarcoma;
Prognosis;
Gene
- From:
Clinical Medicine of China
2022;38(3):279-284
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is a kind of primary malignant tumor of bone originated from mesenchymal tissue, which mainly occurs in children and adolescents, and presents the characteristics of high malignancy, rapid growth, early metastasis and poor prognosis. Currently, most of the studies at home and abroad mainly focused on therapeutic procedures. However, reliable predictors are essential for monitoring disease changes, guiding treatment and evaluating prognosis. In recent years, the research on prognosis related genes of osteosarcoma has become a new hotspot. Its abnormal expression affects the progress, invasion and metastasis of osteosarcoma cells, and plays an important role in drug resistance and chemotherapy of osteosarcoma. This paper briefly summarizes the abnormal expression of genes related to the prognosis of osteosarcoma: miRNAs, Incrna, CircRNA, ErbB gene family and the imbalance of oncogenes and immune related genes, and fully understands their characteristics, in order to provide a new direction and possible new drug treatment target for the early diagnosis and treatment of osteosarcoma patients, so as to improve the prognosis of osteosarcoma patients.
