Treatment of Psoriasis with Calcipotriol-PUVA.
- Author:
Yong Beom CHOE
1
;
Seok Beom PARK
;
Jai Il YOUN
Author Information
1. Department of Dermatology, Seoul National University College of Medicine.
- Publication Type:Original Article
- Keywords:
Psoriasis;
PUVA;
Calcipotriol-PUVA
- MeSH:
Humans;
Photochemotherapy;
Phototherapy;
Psoriasis*;
PUVA Therapy;
Vitamin D
- From:Korean Journal of Dermatology
2000;38(6):772-776
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: PUVA photochemotherapy has been accepted as an effective treatment modality in the treatment of psoriasis. Many combination therapies have been tried to reduce the long-term side effects of UV radiation. OBJECTIVE: We performed conventional PUVA and calcipotriol-PUVA combination therapy to compare the effectiveness between two treatment modalities. METHODS: We treated 38 Korean patients with conventional PUVA and 54 with D-PUVA. We compared the total number, duration and total UVA dose of PUVA therapy to reach grade 4 between two groups. We categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy, and evaluated PASI score at patient`s visits. RESULTS: The irradiation number and total cumulative dose of D-PUVA phototherapy to achieve grade 4 were significantly smaller than PUVA phototherapy. CONCLUSION: Combining PUVA with a vitamin D analogue, calcipotriol, in the treatment of psoriasis may lead to lowering the risk of long-term exposure to UV radiation with higher efficacy.
